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Astral Codex Ten Podcast

Oct 11, 2017

Pop science likes to dub dopamine “the reward chemical” and serotonin “the happiness chemical”. God only knows what norepinephrine is, but I’m sure it’s cutesy.

In real life, all of this is much more complicated. Dopamine might be “the surprisal in a hierarchical predictive model chemical”, but even that can’t be more than a gross oversimplification. As for serotonin, people have studied it for seventy years and the best they can come up with is “uh, something to do with stress”.

Serotonin and brain function: a tale of two receptors by Robin Carhart-Harris and David Nutt tries to cut through the mystery. Both authors are suitably important to attempt such an undertaking. Carhart-Harris is a neuropsychopharmacologist and one of the top psychedelic researchers in the world. Nutt was previously the British drug czar but missed the memo saying drug czars were actually supposed to be against drugs; after using his position to tell everyone drugs were pretty great, he was summarily fired. Now he’s another neuropsychopharmacology professor, though with cool side projects like inventing magical side-effect-free alcohol. These are good people.